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IACS-010759 hydrochloride

IACS-010759 hydrochloride
IACS-010759 is a potent inhibitor of complex I of OXPHOS with orally bioavailable. IACS-10759 effectively inhibits ATP production and oxygen consumption in isolated mitochondria, and inhibits the conversion of NADH to NAD+ in immunoprecipitated complex I in low nM range. IACS-10759 shows significant efficacy in multiple tumor indications both in vitro and in vivo.
Catalog No. T27568Cas No. 1807523-99-4
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IACS-010759 hydrochloride

Catalog No. T27568Alias IACS-010759 HCl, IACS-010759, IACS10759, IACS-10759, IACS 10759Cas No. 1807523-99-4
IACS-010759 is a potent inhibitor of complex I of OXPHOS with orally bioavailable. IACS-10759 effectively inhibits ATP production and oxygen consumption in isolated mitochondria, and inhibits the conversion of NADH to NAD+ in immunoprecipitated complex I in low nM range. IACS-10759 shows significant efficacy in multiple tumor indications both in vitro and in vivo.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
2 mg$685 days
5 mg$1225 days
1 mL x 10 mM (in DMSO)$1625 days
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Other Forms of IACS-010759 hydrochloride:
IACS-010759T53371570496-34-2
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SobetiromeT5313211110-63-3
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Product Introduction

Bioactivity
Description
IACS-010759 is a potent inhibitor of complex I of OXPHOS with orally bioavailable. IACS-10759 effectively inhibits ATP production and oxygen consumption in isolated mitochondria, and inhibits the conversion of NADH to NAD+ in immunoprecipitated complex I
AliasIACS-010759 HCl, IACS-010759, IACS10759, IACS-10759, IACS 10759
Chemical Properties
Molecular Weight599.03
FormulaC25H26ClF3N6O4S
Cas No.1807523-99-4
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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Keywords

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